Moderna

Disclaimer: The information contained here is for educational and entertainment purposes only. Nothing herein is medical or legal advice. You are only encouraged to do your own research.

UNDER HEAVY CONSTRUCTION, COME BACK LATER

Modernatx, Inc. Sars-cov-2 mrna domain vaccines November 4th, 2021


Moderna: SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine compositions


Delivery and formulation of engineered nucleic acids


Same as above. From Moderna website patent program direct:

https://www.modernatx.com/sites/default/files/content_documents/US10898574.pdf

Note: Is there a difference between Moderna and Modernatx? It seems Moderna does have another patent for a Coronavirus vaccine. It was just published November 4th, 2021 and included with the other diabolical stuff prior. So many questions now...


BREAKDOWN: 

Modernatx, Inc. Sars-cov-2 mrna domain vaccines November 4th, 2021


*Moderna: 
SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine compositions


(patent copy)

*Moderna: 
SARS-CoV-2 messenger ribonucleic acid (mRNA) vaccine compositions


In some embodiments, the open reading frame (ORF) sequence is optimized using optimization algorithms.

*SARS-CoV-2 Spike (S) protein
*Messenger RNA (mRNA)
*Synthetic Methods
*Gel electrophoresis
*cDNA
*Method of eliciting an immune response
*Self-assembly / self-assemble
*Enzyme-linked immunosorbent assay (ELISA kit)
*Colloidal silicon oxide
*Magnesium stearate
*Cellulose
*Sodium lauryl sulfate
*Coronavirus antigen
*SARS-CoV-2 antigen
*E. coli

Marker or selection protein:

*Luciferase
*GFP
*EGFP
*b-Galactosidase
*EGFP
*Alpha- Globin
*Galactokinase
*Xanthine:guanine phosphoribosyl *Transferase (GPT)
*Lipid Nanoparticles (LNPs)
*Polyethylene glycol (PEG)
*Prophylactic agents
*Cationic lipid
*Ionizable cationic lipid
*Heptadecan-9-yl 8 ((2 hydroxyethyl)(6 oxo 6-(undecyloxy)hexyl)amino)octanoate (Compound 1)
*Distearoyl-sn-glycero-3-phosphocholine (DSPC)
*Cholesterol
*Chimera / chimeric protein
*UTRs include that of bovine or human growth hormone
*Uridine
*Core-shell nanoparticles
*Peptides
*Proteins
*Cells transfected with the RNA
*Hyaluronidase
*Nanoparticle mimics
*Open reading frame (ORF)
*Optimization algorithms
*Tris buffer
*Sucrose
*Sodium acetate

Purification: 

*Poly-T beads
*AGENCOURT® beads
*Capture probes
*Encapsulin
*Fusion proteins

==========================//

SUPPORTING SOURCES: 

*SARS-CoV-2 Spike (S) protein (The in vitro V(D)J reporter assay shows that the spike protein is hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. The reporter assay shows that the spike protein intensely impeded V(D)J recombination.)


*Messenger RNA (mRNA) (Messenger RNA (mRNA) is a single-stranded RNA molecule that is complementary to one of the DNA strands of a gene. The mRNA is an RNA version of the gene that leaves the cell nucleus and moves to the cytoplasm where proteins are made. During protein synthesis, an organelle called a ribosome moves along the mRNA, reads its base sequence, and uses the genetic code to translate each three-base triplet, or codon, into its corresponding amino acid.) 


*Synthetic Methods (Refers to the methods used for the synthesis of chemical compounds.) 


*Gel electrophoresis



*cDNA
*Method of eliciting an immune response
*Self-assembly / self-assemble
*Enzyme-linked immunosorbent assay (ELISA kit)
*Colloidal silicon oxide
*Magnesium stearate
*Cellulose
*Sodium lauryl sulfate
*Coronavirus antigen
*SARS-CoV-2 antigen
*E. coli

Marker or selection protein:

*Luciferase
*GFP
*EGFP
*b-Galactosidase
*EGFP
*Alpha- Globin
*Galactokinase
*Xanthine:guanine phosphoribosyl *Transferase (GPT)
*Lipid Nanoparticles (LNPs)
*Polyethylene glycol (PEG)
*Prophylactic agents
*Cationic lipid
*Ionizable cationic lipid
*Heptadecan-9-yl 8 ((2 hydroxyethyl)(6 oxo 6-(undecyloxy)hexyl)amino)octanoate (Compound 1)
*Distearoyl-sn-glycero-3-phosphocholine (DSPC)
*Cholesterol
*Chimera / chimeric protein
*UTRs include that of bovine or human growth hormone
*Uridine
*Core-shell nanoparticles
*Peptides
*Proteins
*Cells transfected with the RNA
*Hyaluronidase
*Nanoparticle mimics
*Open reading frame (ORF)
*Optimization algorithms
*Tris buffer
*Sucrose
*Sodium acetate

Purification: 

*Poly-T beads
*AGENCOURT® beads
*Capture probes
*Encapsulin
*Fusion proteins


==========================//

Conclusions:




==========================//

Newest pdf added to the program patent. 

Delivery and formulation of engineered nucleic acids




OTHER PATENT BRANDS:

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