Pfizer patent
//===============Start TABLE OF CONTENTS: *Wireless / wireless technologies *Self- assemble *SARS-CoV-2-encoded polypeptide *Immunoreactive epitopes of a SARS-CoV-2 *(Poly)cationic polymer *Olyepitope immunogenic compositions *Spike protein *m2 7'3 '-OGppp(m1 2 '-O)ApG *cDNA *Microsphere *Green fluorescent protein (GFP) *Luciferase *MicroBead *Aluminium hydroxide Encoding mechanism: *UTR sequence / untranslated region *Open reading frame / ORF *Polyepitope immunogenic compositions *Ionizable cationic lipid *1,2-distearoyl-sn-glycero-3-phosphocholine *PEG2000 DMG Vaccine-induced T cells Vaccine antigen Protein antigen *Modified cytidine *Trimeric protein / trimeric receptor *Foldon *Algorithm parameters / BLASTP algorithm *RNA 5- methylcytidine *(SA)-fluorochrome conjugates *Codon *Electrophoresis *Epitopes: HLA-B*0702 HLA-A*2402 HLA- B*3501 HLA-B*4401 HLA-A*0201 FILA-A*0201 YLQPRTFLL HLA-A*0201 RLQSLQTYV HLA-A*2402 QYIKWPWYI HLA-A*2402 NYNYLYRLF HLA-A*2402 KWPWYIWLGF HLA-B*3501 QPTESIVRF HLA-B*3501 IPFAMQMAY HLA-B*3501 LPFNDGVYF *Uridines (in the RNA): 3-methyl-uridine (m3U) 5-methoxy-uridine (mo5U) 5-aza- uridine 6-aza-uridine 2-thio-5-aza-uridine 2-thio-uridine (s2U) 4-thio-uridine (s4U) 4-thio- pseudouridine 2-thio-pseudouridine 5-hydroxy-uridine (ho5U) 5-aminoallyl-uridine 5-iodo-uridine or 5-bromo-uridine Uridine 5-oxyacetic acid (cmo5U) Uridine 5- oxyacetic acid methyl ester (mcmo5U) 5-carboxymethyl-uridine (cm5U) 1-carboxymethyl- pseudouridine 5-carboxyhydroxymethyl-uridine (chm5U) 5-carboxyhydroxymethyl-uridine methyl ester (mchm5U) 5-methoxycarbonylmethyl-uridine (mcm5U) 5- methoxycarbonylmethyl-2-thio-uridine (mcm5s2U) 5-aminomethyl-2-thio-uridine (nm5s2U) 5-methylaminomethyl-uridine (mnm5U) 1-ethyl-pseudouridine 5-methylaminomethyl-2- thio-uridine (mnm5s2U) 5-methylaminomethyl-2-seleno-uridine (mnm5se2U) 5- carbamoylmethyl-uridine (ncm5U) 5-carboxymethylaminomethyl-uridine (cmnm5U) 5- carboxymethylaminomethyl-2-thio-uridine (cmnm5s2U) 5-propynyl-uridine, 1-propynyl- pseudouridine 5-taurinomethyl-uridine (tm5u) 1-taurinomethyl-pseudouridine 5- taurinomethyl-2-thio-uridine(τm5s2U) 1-taurinomethyl-4-thio-pseudouridine 5-methyl-2- thio-uridine (m5s2U) 1-methyl-4-thio-pseudouridine (m1s4Ψ) 4-thio-1-methyl-pseudouridine 3-methyl-pseudouridine (m3Ψ ) 2-thio-1-methyl-pseudouridine 1-methyl-1-deaza- pseudouridine 2-thio-1-methyl-1-deaza-pseudouridine dihydrouridine (D) dihydropseudouridine 5,6-dihydrouridine 5-methyl-dihydrouridine (m5D) 2-thio- dihydrouridine 2-thio-dihydropseudouridine 2-methoxy-uridine 2-methoxy-4-thio-uridine 4-methoxy-pseudouridine 4-methoxy-2-thio-pseudouridine N1-methyl-pseudouridine 3-(3- amino-3-carboxypropyl)uridine (acp3U) 1-methyl-3-(3-amino-3- carboxypropyl)pseudouridine (acp3 Ψ ) 5-(isopentenylaminomethyl)uridine (inm5U) 5- (isopentenylaminomethyl)-2-thio-uridine (inm5s2U) a-thio-uridine, 2'-O-methyl-uridine (Um) 5,2'-O-dimethyl-uridine (m5Um) 2'-O-methyl-pseudouridine (Ψ m) 2-thio-2'-O-methyl- uridine (s2Um) 5-methoxycarbonylmethyl-2'-O-methyl-uridine (mcm5Um) 5- carbamoylmethyl-2'-O-methyl-uridine (ncm5Um) 5-carboxymethylaminomethyl-2'-O- methyl-uridine (cmnm5Um) 3,2'-O-dimethyl-uridine (m3Um) 5-(isopentenylaminomethyl)-2'- O-methyl-uridine (inm5Um) 1-thio-uridine, deoxythymidine 2'-F-ara-uridine, 2'-F-uridine 2'- OH-ara-uridine 5-(2-carbomethoxyvinyl) uridine 5-[3-(1-E-propenylamino)uridine Any other modified uridine *Lipids: ((4-hydroxybutyl)azanediyl)bis(hexane-6,l- diyl)bis(2-hexyldecanoate) 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide 1,2- Distearoyl-sn-glycero-3-phosphocholine Cholesterol Glycerolipids Glycerophospholipids Sphingolipids Sterol lipids Saccharolipids Polyketides Prenol lipids Triglycerides Protonation (capable of being protonated) Cationic lipids: *1,2-dioleoyl-3-trimethylammonium propane (DOTAP) *N,N-dimethyl-2,3-dioleyloxypropylamine (DODMA) *1,2-di-O-octadecenyl- 3-trimethylammonium propane (DOTMA) *3-(N— (N',N'-dimethylaminoethane)- carbamoyl)cholesterol (DC-Chol) *dimethyldioctadecylammonium (DDAB) *1,2-dioleoyl-3- dimethylammonium-propane (DODAP) *1,2-diacyloxy-3-dimethylammonium propanes *1,2- dialkyloxy-3-dimethylammonium propanes *dioctadecyldimethyl ammonium chloride (DODAC) *1,2- distearyloxy-N,N-dimethyl-3-aminopropane (DSDMA) *2,3- di(tetradecoxy)propyl-(2-hydroxyethyl)-dimethylazanium (DMRIE) *1,2-dimyristoyl-sn- glycero-3-ethylphosphocholine (DMEPC) *1,2-dimyristoyl-3-trimethylammonium propane (DMTAP) *1,2-dioleyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide (DORIE) *2,3-dioleoyloxy- N-[2(spermine carboxamide)ethyl]-N *N-dimethyl-l-propanamium trifluoroacetate (DOSPA) *1,2- dilinoleyloxy-N,N-dimethylaminopropane (DLinDMA) *1,2- dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA) *dioctadecylamidoglycyl spermine (DOGS) *3-dimethylamino-2-(cholest-5-en-3-beta-oxybutan-4-oxy)-1-(cis,cis-9 *12-oc- tadecadienoxy)propane (CLinDMA) *2-[5'-(cholest-5-en-3-beta-oxy)-3'-oxapentoxy)-3- dimethyl-1-(cis,cis-9',12'-octadecadienoxy)propane (CpLinDMA) *N,N-dimethyl-3,4- dioleyloxybenzylamine (DMOBA) *1,2-N,N'-dioleylcarbamyl-3-dimethylaminopropane (DOcarbDAP) *2,3-Dilinoleoyloxy-N,N-dimethylpropylamine (DLinDAP) *1,2-N,N'- Dilinoleylcarbamyl-3-dimethylaminopropane (DLincarbDAP) *1,2-Dilinoleoylcarbamyl-3- dimethylaminopropane (DLinCDAP) *2,2-dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA) *2,2-dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane (DLin-K-XTC2-DMA) *2,2- dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane (DLin-KC2-DMA) *heptatriaconta- 6,9,28,31-tetraen-19-yl-4-(dimethylamino)butanoate (DLin-MC3-DMA) *N-(2-Hydroxyethyl)- N,N-dimethyl-2,3-bis(tetradecyloxy)-1-propanaminium bromide (DMRIE) *(±)-N-(3- aminopropyl)-N,N-dimethyl-2,3-bis(cis-9-tetradecenyloxy)-1-propanaminium bromide (GAP- DMORIE) *(±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(dodecyloxy)-1-propanaminium bromide (GAP-DLRIE) *(±)-N-(3-aminopropyl)-N,N-dimethyl-2,3-bis(tetradecyloxy)-1- propanaminium bromide (GAP-DMRIE) *N-(2-Aminoethyl)-N,N-dimethyl-2,3- bis(tetradecyloxy)-1-propanaminium bromide (bAE-DMRIE) *N-(4-carboxybenzyl)-N,N- dimethyl-2,3-bis(oleoyloxy)propan-1-aminium (DOBAQ) *2-({8-[(3β)-cholest-5-en-3- yloxy]octyl}oxy)-N,N-dimethyl-3-[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propan-1-amine (Octyl-CLinDMA) *1,2-dimyristoyl-3-dimethylammonium-propane (DMDAP) *1,2-dipalmitoyl- 3-dimethylammonium-propane (DPDAP) *N1-[2-((lS)-1-[(3-aminopropyl)amino]-4-[di(3- amino-propyl)amino]butylcarboxamido)ethyl]-3,4-di[oleyloxy]-benzamide (MVL5) *1,2- dioleoyl-sn-glycero-3-ethylphosphocholine (DOEPC) *2,3-bis(dodecyloxy)-N-(2-hydroxyethyl)- N,N-dimethylpropan-1-amonium bromide (DLRIE) *N-(2-aminoethyl)-N,N-dimethyl-2,3- bis(tetradecyloxy)propan-1-aminium bromide (DMORIE) *di((Z)-non-2-en-1-yl) 8,8'- *((((2(dimethylamino)ethyl)thio)carbonyl)azanediyl)dioctanoate (ATX) *N,N-dimethyl-2,3- bis(dodecyloxy)propan-1-amine (DLDMA) *N,N-dimethyl-2,3-bis(tetradecyloxy)propan-1- amine (DMDMA) *Di((Z)-non-2-en-1-yl)-9-((4- *(dimethylaminobutanoyl)oxy)heptadecanedioate (L319)*N-Dodecyl-3-((2-dodecylcarbamoyl- ethyl)-{2-[(2-dodecylcarbamoyl-ethyl)-2-{(2-dodecylcarbamoyl-ethyl)-[2-(2- dodecylcarbamoyl-ethylamino)-ethyl]-amino}-ethylamino)propionamide (lipidoid 98N12-5)
*1- [2-[bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2 hydroxydodecyl)amino]ethyl]piperazin- l-yl]ethyl]amino]dodecan-2-ol (lipidoid C12-200) *Cationically ionizable lipid *Lipid Nanoparticles: Lipid nanoparticles / (LPN) Lipoplex / (LPX) LNP particles comprise ((4-hydroxybutyl)azanediyl)bis(hexane-6,l- diyl)bis(2-hexyldecanoate) 2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide 1,2- Distearoyl-sn-glycero-3-phosphocholine *Hydrophobicity / hydrophilic groups: Carbohydrates Phosphate Carboxylic Sulfate Amino Sulfhydryl Nitro Hydroxyl *Preservatives: Benzalkonium chloride Chlorobutanol Paraben Thimerosal Salts *Carrier: Sterile water Ringer Ringer lactate Sterile sodium chloride solution Isotonic saline Polyalkylene glycols Hydrogenated naphthalenes Biocompatible lactide polymers Lactide/glycolide copolymers Polyoxyethylene/polyoxy-propylene copolymers Animal / fish / insect cells: *Fetal bovine serum *Protamine (salmon sperm) *Spermine *Polyalkyleneimine *Green fluorescent protein (GFP) *Luciferase *Cytokines: Th1-dominant cytokine BNT162b1-induced T cells Chemokines Interferon / IFN Interleukin / IL Lymphokines Tumor necrosis factor / (TNF) Adjuvants (may comprise): LPS GP96 CpG oligodeoxynucleotides *growth factors *monokines *lymphokines *chemokines 4-hydroxybutyl)azanediylbis(hexane-6,l- diyl)bis(2-hexyldecanoate) *2-[(polyethylene glycol)-2000]-N N-ditetradecylacetamide 1,2- Distearoyl-sn-glycero-3-phosphocholine Cryo-electron microscopy //===============End SUMMARY AND SOURCES: Additional Related Information: Independent Microscopy: Conclusion and opinion: SUMMARY AND SOURCES:
*Wireless / wireless technologies (It is mentioned in the patent, but it doesn't specify if it's just for the packaging)
What is cDNA?
https://www.sciencedirect.com/topics/neuroscience/complementary-dna
The Supreme Court has made rulings on cDNA being patentable.
https://www.supremecourt.gov/opinions/12pdf/12-398_1b7d.pdfDNA barcodes
https://pubs.rsc.org/en/content/articlehtml/2017/cs/c7cs00271h
Luciferase gene of differentiation state certification mark gene. (Ag/Au nanowires can be read as 0s and 1s for scanning barcode. Can be used in part for product barcoding and identification. Perhaps the gold is read as 0 and the iron as 1 based on magnetism and non-magnetism? Coincidentally all barcodes must always contain the number 666 for the computer to be read correctly.)
This is not from the Covid-19 vaccine patent, but it gives information about Luciferase.
https://patents.google.com/patent/CN102822333A/en
Biosynthesis of Au, Ag and Au–Ag bimetallic NPs using the protein extracts.
Teslaphoresis a University laboratory video demonstration
*Open reading frame (encoding a full-length SARS-CoV-2 S protein, ORF contains no stop codons.)
See microwells, beads Other Pfizer mRNA related patents: https://patents.google.com/patent/CA2998554A1 https://patents.google.com/patent/CA3087442A1 https://patents.google.com/patent/WO2021155916A1 https://patents.google.com/patent/US10968280B2 https://patents.google.com/patent/US10729784B2 https://patents.google.com/patent/AU2013343864B2 https://patents.google.com/patent/WO2021058091A1 https://patents.google.com/patent/CA2621444C/en https://patents.google.com/patent/US10952972B2/
Conclusion and opinion:There are a many concerns with this patent. But this patent seems to describe a legitimate vaccine. It seems designed around safety as well. Some contents may only be limited to research purposes, but it's difficult to be certain at times. Also other Pfizer patents listed above are concerning. They also include mRNA technology and may relate to the main Coronavirus vaccine patent. It seems they could have created separate patents to hide the concerns. Here's one (mRNA patent) that I was working out for example. https://xyz3000.blogspot.com/2021/11/ugur-sahin-patents.html Moderna also has separate patents, but they are listed under the same program. So it's very possible this could be the case. Many people are experiencing a vaierty of adverse affects from Pfizer and Moderna. So that is why I strongly hold to this opinion.
OTHER PATENT BRANDS:
Under Heavy Construction
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